Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC
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چکیده
منابع مشابه
Sodium dichloroacetate selectively targets cells with defects in the mitochondrial ETC.
The "Warburg effect," also termed aerobic glycolysis, describes the increased reliance of cancer cells on glycolysis for ATP production, even in the presence of oxygen. Consequently, there is continued interest in inhibitors of glycolysis as cancer therapeutics. One example is dichloroacetate (DCA), a pyruvate mimetic that stimulates oxidative phosphorylation through inhibition of pyruvate dehy...
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ژورنال
عنوان ژورنال: International Journal of Cancer
سال: 2010
ISSN: 0020-7136
DOI: 10.1002/ijc.25499